Piper, B. J. et al. Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep. J Psychopharmacol. 31, 569–575 (2017).
Google Scholar
Hill, K. P. & Weiss, R. D. Minimal physical health risk associated with long-term cannabis use—but buyer beware. JAMA. 315, 2338–2339 (2016).
Google Scholar
Rubin, R. Medical marijuana is legal in most states, but physicians have little evidence to guide them. JAMA. 317, 1611–1613 (2017).
Google Scholar
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. Washington (DC): National Academies Press (US) (2017).
Stith, S. S. & Vigil, J. M. V. Federal barriers to Cannabis research. Science. 352, 1182 (2016).
Google Scholar
Di Forti, M. et al. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study. The Lancet Psychiatry. 2, 233–238 (2015).
Google Scholar
Gage, S. H. et al. Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychological Medicine. 47, 971–980 (2017).
Google Scholar
Fakhoury, M. Could cannabidiol be used as an alternative to antipsychotics? Journal of Psychiatric Research. 80, 14–21 (2016).
Google Scholar
Gururajan, A. & Malone, D. T. Does cannabidiol have a role in the treatment of schizophrenia? Schizophrenia Research. 176, 281–290 (206).
Iseger, T. A. & Bossong, M. G. A systematic review of the antipsychotic properties of cannabidiol in humans. Schizophrenia Research. 162, 153–161 (2015).
Google Scholar
Christian, D. et al. Cannabis with high cannabidiol content is associated with fewer psychotic experiences. Schizophrenia Research. 130, 216–221 (2011).
Google Scholar
National Institute of Drug Abuse. Marijuana as Medicine, https://www.drugabuse.gov/publications/drugfacts/marijuana-medicine on (2018).
Ramo, D. E., Popova, L., Grana, R., Zhao, S. & Chavez, K. Cannabis Mobile Apps: A Content Analysis. Eysenbach G, ed. JMIR mHealth and uHealth. 3, e81 (2015).
ReleafApp, https://releafapp.com/ (2018).
Vigil, J. M., Stith, S. S., Adams, I. M. & Reeve, A. P. Associations between medical cannabis and prescription opioid use in chronic pain patients: A preliminary cohort study. PLoS ONE. 12, e0187795 (2017).
Google Scholar
Kindred, J. H. et al. Cannabis use in people with Parkinson’s disease and Multiple Sclerosis: A web-based investigation. Complementary Therapies in Medicine. 33, 99–104 (2017).
Google Scholar
Bonn-Miller, M. O., Babson, K. A. & Vandrey, R. Using cannabis to help you sleep: Heightened frequency of medical cannabis use among those with PTSD. Drug and Alcohol Dependence. 136, 162–165 (2014).
Google Scholar
Costain, W. F. The effects of cannabis abuse on the symptoms of schizophrenia: Patient perspectives. International Journal of Mental Health Nursing. 17, 227–235 (2008).
Google Scholar
MacCallum, C. A. & Russo, E. B. Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine. 49, 12–19 (2018).
Google Scholar
Fischer, B. et al. Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health. 107, e1–e12 (2017).
Google Scholar
Stith, S. S., Vigil, J. M., Brockelman, F., Keenan, K. & Hall, B. Patient-reported symptom relief following medical cannabis consumption. Frontiers in Pharmacology. 9, 916, https://www.frontiersin.org/articles/10.3389/fphar.2018.00916/full (2018).
Vigil, J. M. et al. Effectiveness of raw, natural medical Cannabis flower for treating insomnia under naturalistic conditions. Medicines. 5, 75. https://www.mdpi.com/2305-6320/5/3/75 (2018).
Blundell, M., Dargan, P. & Wood, D. A cloud on the horizon-a survey into the use of electronic vaping devices for recreational drug and new psychoactive substance (NPS) administration. QJM. 111, 9–14 (2018).
Google Scholar
Eggers, M. E. et al. Youth use of electronic vapor products and blunts for administering cannabis. Addictive Behaviors. 70, 79–82 (2017).
Google Scholar
Marijuana Policy Project, https://www.mpp.org/issues/medical-marijuana/state-by-state-medical-marijuana-laws/medical-marijuana-patient-numbers/ (2018).
Dinis-Oliveira, R. J. Metabolomics of Δ9-tetrahydrocannabinol: implications in toxicity. Drug Metabolism Reviews. 48, 80–87 (2016).
Google Scholar
Lefever, T. W. et al. Vaping synthetic cannabinoids: A novel preclinical model of e-cigarette use in mice. Substance Abuse: Research and Treatment. 11, https://doi.org/10.1177/1178221817701739 (2017).
Manwell, L. A. et al. A vapourized Δ9-tetrahydrocannabinol (Δ9-THC) delivery system part I: Development and validation of a pulmonary cannabinoid route of exposure for experimental pharmacology studies in rodents. Journal of Pharmacological and Toxicological Methods. 70, 120–127 (2014).
Google Scholar
Nguyen, J. D. et al. Inhaled delivery of Δ9-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology. Neuropharmacology. 109, 112–120 (2016).
Google Scholar
Vandrey, R. et al. Pharmacokinetic profile of oral cannabis in humans: Blood and oral fluid disposition and relation to pharmacodynamic outcomes. Journal of Analytical Toxicology. 41, 83–99 (2017).
Google Scholar
Varlet, V. et al. Drug vaping applied to cannabis: Is “Cannavaping” a therapeutic alternative to marijuana? Scientific Reports. 6, 25599, https://www.nature.com/articles/srep25599 (2016).
Cohen, N. L., Heinz, A. J., Ilgen, M. & Bonn-Miller, M. O. Pain, Cannabis Species, and Cannabis Use Disorders. Journal of Studies on Alcohol and Drugs. 77, 515–520 (2016).
Google Scholar
Pearce, D., Mitsouras, K. & Irizarry, K. Discriminating the Effects of Cannabis sativa and Cannabis indica: A Web Survey of Medical Cannabis Users. Journal of Alternative & Complementary Medicine. 20, 787–791 (2014).
Google Scholar
Andreae, M. H. et al. Inhaled cannabis for chronic neuropathic pain: an individual patient data meta-analysis. The Journal of Pain. 16, 1221–1232 (2015).
Google Scholar
Mücke, M., Phillips, T., Radbruch, L., Petzke, F. & Häuser, W. Cannabis-based medicines for chronic neuropathic pain in adults. Cochrane Database of Systematic Reviews. 3, Art. No.: CD012182. https://doi.org/10.1002/14651858.CD012182.pub2 (2018).
Belendiuk, K. A., Babson, K. A., Vandrey, R. & Bonn-Miller, M. O. Cannabis species and cannabinoid concentration preference among sleep-disturbed medicinal cannabis users. Addictive Behaviors. 50, 178–181 (2015).
Google Scholar
Bonn-Miller, M. O. et al. Labeling accuracy of cannabidiol extracts sold online. JAMA. 318, 1708–1709 (2017).
Google Scholar
Burstein, S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry. 23, 1377–1385 (2017).
Google Scholar
McPartland, J. M., Duncan, M., Di Marzo, V. & Pertwee, R. G. Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. British Journal of Pharmacology. 172, 737–753 (2015).
Google Scholar
Piano, M. Cannabis smoking and cardiovascular health: It’s complicated. Clin. Pharmacol. Ther. 102, 191–193 (2017).
Google Scholar
Richards, J. R. Cannabinoid hyperemesis syndrome: Pathophysiology and treatment in the emergency department. Journal of Emergency Medicine. 54, 354–363 (2018).
Google Scholar
Fowler, C. Delta9-tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature. Clin. Pharmacol. Ther. 97, 587–596 (2015).
Google Scholar
Śledziński, P., Zeyland, J., Słomski, R. & Nowak, A. The current state and future perspectives of cannabinoids in cancer biology. Cancer Medicine. 7, 765–775 (2018).
Google Scholar
