ElSohly, M. & Gul, W. Constituents of cannabis sativa. In Handbook of cannabis (ed. Pertwee, R.) 3–22 (Oxford University Press, 2014).
Wright, S. & Metts, J. Recreational cannabinoid use: the hazards behind the “high”. J. Fam. Pract. 65(11), 770–776 (2016).
Google Scholar
Grotenhermen, F. Cannabis and Cannabinoids-Pharmacology, Toxicology, and Therapeutic Potential (eds Grotenhermen, F. & Russo, E.) 55–65 (Haworth Press, 2002).
Pertwee, R. G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br. J. Pharmacol. 153(2), 199–215 (2008).
Google Scholar
Adams, R., Hunt, M. & Clark, J. H. Structure of cannabidiol, a product isolated from the marihuana extract of Minnesota wild hemp. J. Am. Chem. Soc. 62(1), 196–200 (1940).
Google Scholar
Consroe, P. Brain cannabinoid systems as targets for the therapy of neurological disorders. Neurobiol. Dis. 5(6), 534–551 (1998).
Google Scholar
Izzo, A. A., Borrelli, F., Capasso, R., Di Marzo, V. & Mechoulam, R. Cannabinoidi vegetali non psicotropi: nuove opportunità terapeutiche da un’erba antica. Trends Pharmacol. Sci. 30, 515–527 (2009).
Google Scholar
McPartland, J. M. & Russo, E. B. Cannabis and cannabis extracts: greater than the sum of their parts? J. Cannabis Ther. 1(3-4), 103–132 (2001).
Google Scholar
Mechoulam, R., Parker, L. A. & Gallily, R. Cannabidiol: an overview of some pharmacological aspects. J. Clin. Pharmacol. 42(S1), 11S–19S (2002).
Google Scholar
Mechoulam, R. & Hanuš, L. Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. Chem. Phys. Lipids 121(1-2), 35–43 (2002).
Google Scholar
Laprairie, R. B., Bagher, A. M., Kelly, M. E. M. & Denovan-Wright, E. M. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br. J. Pharmacol. 172(20), 4790–4805 (2015).
Google Scholar
Hawksworth, G. & McArdle, K. Metabolism and pharmacokinetics of cannabinoids. In The Medicinal Uses of Cannabis and Cannabinoids (eds. Guy, G.W., Whittle, B.A. & Robson, P.J.) 205–228 (Pharmaceutical Press: London 2004).
Fasinu, P. S., Phillips, S., ElSohly, M. A. & Walker, L. A. Current status and prospects for cannabidiol preparations as new therapeutic agents. Pharmacotherapy 36(7), 781–796 (2016).
Google Scholar
Ohlsson, A. et al. Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration. Biomed. Environ. Mass. Spectrom. 13(2), 77–83 (1986).
Google Scholar
Iffland, K. & Grotenhermen, F. An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies. Cannabis Cannabinoid Res. 2(1), 139–154 (2017).
Google Scholar
Eggers, M. E. et al. Youth use of electronic vapor products and blunts for administering cannabis. Addict. behav. 70, 79–82 (2017).
Google Scholar
de Lacy, E., Fletcher, A., Hewitt, G., Murphy, S. & Moore, G. Cross-sectional study examining the prevalence, correlates and sequencing of electronic cigarette and tobacco use among 11–16-year olds in schools in Wales. BMJ open, 7(2), e012784 (2017).
Google Scholar
Electronic Nicotine Delivery Systems. (World Health Organisation (WHO) Framework Convention on Tobacco Control, 2014).
Ogunwale, M. A. et al. Aldehyde detection Electron. Cigar. aerosols. ACS omega 2(3), 1207–1214 (2017).
Google Scholar
Kosmider, L. et al. Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob. Res. 16(10), 1319–1326 (2014).
Google Scholar
Warning Letters and Test Results. (United States Food and Drug Administration, 2015b).
Peace, M. R., Butler, K. E., Wolf, C. E., Poklis, J. L. & Poklis, A. Evaluation of two commercially available cannabidiol formulations for use in electronic cigarettes. Front. Pharmacol. 7, 279 (2016).
Google Scholar
Warning letters and test results for cannabidiol-related products. (US Food and Drug Administration, 2017).
Trofin, I. G., Dabija, G., Vaireanu, D. I. & Filipescu The influence of long-term storage conditions on the stability of cannabinoids derived from cannabis resin. Rev. Chim. Buchar. 63(4), 422–427 (2012).
Google Scholar
USP 26: The United States Pharmacopeia: 26. Rev.; NF 21: the National Formulary: 21. Ed. Supplement (USPC, 2003).
Bonn-Miller, M. O. et al. Labeling accuracy of cannabidiol extracts sold online. Jama 318(17), 1708–1709 (2017).
Google Scholar
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